What OS do you have? Windows or Mac?
What art program(s) are you trying to use with your tablet?
Are you sure you have the latest
driver installed for it? Just in case, I'll link the most current drivers if you want to re-download them again. (These are for the Wacom Intuos Pro series, which you said you have.)
Mac Driver: Click
Windows Driver: Click
Do you hear the connect/disconnect noise your computer makes when you plug/unplug a device?
How old is your tablet?